STUDY: Egg Yolk Shown to Inhibit Spike Protein from SARS-CoV-2

Studies (and here) have shown that the immunoglobulin IgY derived from chicken eggs can inhibit the spike protein from SARS-CoV-2 and protect against COVID-19.

Coronavirus disease (COVID)-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has become a global pandemic disease that has social and economic chaos. An alternative mitigation strategy may involve the use of specific immunoglobulin (Ig)-Y derived from chicken eggs. Our study aimed to evaluate the neutralizing potential of specific IgY targeting S1, receptor-binding-domain (RBD) of spike glycoprotein and nucleocapsid (N) of SARS-CoV-2 to inhibit RBD and angiotensin-converting-enzyme-2 (ACE2) binding interaction. Hy-Line Brown laying hens were immunized with recombinant S1, RBD spike glycoprotein, and nucleocapsid (N) of SARS-CoV-2. The presence of specific S1,RBD,N-IgY in serum and egg yolk was verified by indirect enzyme-linked immunosorbent assay (ELISA). Specific S1,RBD,N-IgY was purified and characterized from egg yolk using sodium-dodecyl-sulfate-polyacrylamide-gel-electrophoresis (SDS-PAGE), and was subsequently evaluated for inhibition of the RBD-ACE2 binding interaction in vitro. Specific IgY was present in serum at 1 week post-initial immunization (p.i.i), whereas its present in egg yolk was confirmed at 4 weeks p.i.i. Specific S1,RBD,N-IgY in serum was able to inhibit RBD-ACE2 binding interaction between 4 and 15 weeks p.i.i. The results of the SDS-PAGE revealed the presence of bands with molecular weights of 180 kDa, indicating the presence of whole IgY. Our results demonstrated that S1,RBD,N-IgY was able to inhibit RBD-ACE2 binding interaction in vitro, suggesting its potential use in blocking virus entry. Our study also demonstrated proof-of-concept that laying hens were able to produce this specific IgY, which could block the viral binding and large production of this specific IgY is feasible.

And

The SARS-CoV-2 virus is still spreading worldwide, and there is an urgent need to effectively prevent and control this pandemic. This study evaluated the potential efficacy of Egg Yolk Antibodies (IgY) as a neutralizing agent against the SARS-CoV-2. We investigated the neutralizing effect of anti-spike-S1 IgYs on the SARS-CoV-2 pseudovirus, as well as its inhibitory effect on the binding of the coronavirus spike protein mutants to human ACE2. Our results show that the anti-Spike-S1 IgYs showed significant neutralizing potency against SARS-CoV-2 pseudovirus, various spike protein mutants, and even SARS-CoV in vitro. It might be a feasible tool for the prevention and control of ongoing COVID-19.

This could explain why there has been a war on eggs specifically.

Here’s a list of food manufacturing and processing plants that have been destroyed since Build Back Better has been in office:

1. 4/30/21 Monmouth Smithfield Foods pork processing plant

2. 7/25/21 Memphis Kellogg plant

3. 8/13/21 JBS beef plant

4. 8/24/21 Patak Meat Company

5. 7/30/21 Tyson River Valley ingredient plant

6. 10/21/21 Darigold plant

7. 11/15/21 Garrard County food plant

8. 11/29/21 Maid-Rite Steak Company

9. 12/13/21 San Antonio food processing, West side Foods

10. 1/7/22 Hamilton Mountain poultry processing

Plant

11. 1/13/22 Cargill-Nutrene feed mill. Lacombe, La

12. 1/31/22 Winston-Salem fertilizer plant

13. 2/3/22 Wisconsin River Meats

14. 2/3/22 Percy dairy farm

15. 2/5/22 Wisconsin River Meats processing facility destroyed by fire in Mauston, Wisconsin.

16. 2/15/22 Bonanza Meat Company goes up in flames in El Paso, Texas

17. 2/15/22 Shearer’s Foods Food processing plant explodes in Hermiston, Oregon.

18. 2/16/22 Indiana Louis-Dreyfus soy processing plant

19. 2/18/22 Bess View Farms

20. 2/19/22 Lincoln premiere poultry

21. 2/22/22 Shearer’s Foods potato chip plant

22. 2/22/22 Fire destroys Deli Star Meat Plant in Fayetteville, Illinois.

23. 2/28/22 nutrient AG Solutions fertilizer facility burns

24. 2/28/22 Shadow Brook Farm & Dutch girl Creamery burns

25 3/4/22 294,800 chickens destroyed at farm in Stoddard, Missouri
26 3/4/22 644,000 chickens destroyed at egg farm in Cecil, Maryland
27 3/8/22 243,900 chickens destroyed at egg farm in New Castle, Delaware
28 3/10/22 663,400 chickens destroyed at egg farm in Cecil, Maryland
29 3/10/22 915,900 chickens destroyed at egg farm in Taylor, Iowa
31 3/14/22 2,750,700 chickens destroyed at egg farm in Jefferson, Wisconsin
34 3/17/22 5,347,500 chickens destroyed at egg farm in Buena Vista, Iowa
35 3/17/22 147,600 chickens destroyed at farm in Kent, Delaware
36 3/18/22 315,400 chickens destroyed at egg farm in Cecil, Maryland
38 3/22/22 172,000 Turkeys destroyed on farms in South Dakota
39 3/22/22 570,000 chickens destroyed at farm in Butler, Nebraska
41 3/24/22 418,500 chickens destroyed at farm in Butler, Nebraska
42 3/25/22 250,300 chickens destroyed at egg farm in Franklin, Iowa
43 3/26/22 311,000 Turkeys destroyed in Minnesota
44 3/27/22 126,300 Turkeys destroyed in South Dakota
45 3/28/22 1,460,000 chickens destroyed at egg farm in Guthrie, Iowa
48 3/31/22 76,400 Turkeys destroyed in Osceola, Iowa
49 3/31/22 5,011,700 chickens destroyed at egg farm in Osceola, Iowa
50 4/6/22 281,600 chickens destroyed at farm in Wayne, North Carolina
51 4/9/22 76,400 Turkeys destroyed in Minnesota
52 4/9/22 208,900 Turkeys destroyed in Minnesota
58 4/13/22 77,000 Turkeys destroyed in Minnesota
53 4/12/22 89,700 chickens destroyed at farm in Wayne, North Carolina
54 4/12/22 1,746,900 chickens destroyed at egg farm in Dixon, Nebraska
55 4/12/22 259,000 chickens destroyed at farm in Minnesota
61 4/14/22 99,600 Turkeys destroyed in Minnesota
62 4/15/22 1,380,500 chickens destroyed at egg farm in Lancaster, Minnesota
64 4/19/22 339,000 Turkeys destroyed in Minnesota
65 4/19/22 58,000 chickens destroyed at farm in Montrose, Colorado
66 4/20/22 2,000,000 chickens destroyed at egg farm in Minnesota
68 4/22/22 197,000 Turkeys destroyed in Minnesota
69 4/23/22 200,000 Turkeys destroyed in Minnesota
70 4/25/22 1,501,200 chickens destroyed at egg farm Cache, Utah
71 4/26/22 307,400 chickens destroyed at farm Lancaster Pennsylvania
72 4/27/22 2,118,000 chickens destroyed at farm Knox, Nebraska
73 4/28/22 Egg-laying facility in Iowa kills 5.3 million chickens, fires 200-plus workers
74 4/28/22 Allen Harim Foods a chicken processing company based in Delaware killed nearly 2 million chickens
75 4/2822 110,700 Turkeys destroyed Barron Wisconsin
76 4/29/22 1,366,200 chickens destroyed at farm Weld Colorado
77 4/30/22 13,800 chickens destroyed at farm Sequoia Oklahoma
78 5/3/22 58,000 Turkeys destroyed Barron Wisconsin
79 5/3/22 118,900 Turkeys destroyed Beadle S Dakota
80 5/3/22 114,000 ducks destroyed at Duck farm Berks Pennsylvania
81 5/3/22 118,900 Turkeys destroyed Lyon Minnesota
82 5/7/22 20,100 Turkeys destroyed Barron Wisconsin
83 5/10/22 72,300 chickens destroyed at farm Lancaster Pennsylvania
84 5/10/22 61,000 ducks destroyed at Duck farm Berks Pennsylvania
85 5/10/22 35,100 Turkeys destroyed Muskegon, Michigan
86 5/13/22 10,500 Turkeys destroyed Barron Wisc
87 5/14/22 83,400 ducks destroyed at Duck farm Berks Pennsylvania
88 5/17/22 79,00 chickens destroyed at Duck farm Berks Pennsylvania
89 5/18/22 7,200 ducks destroyed at Duck farm Berks Pennsylvania
91 5/21/22 57,000 Turkeys destroyed on farm in Dakota Minnesota
92 5/23/22 4,000 ducks destroyed at Duck farm Berks Pennsylvania
93 5/29/22 200,000 Chickens killed in fire in Minnesota
94 5/31/22 3,000,000 chickens chickens destroyed at Forsman egg farm facility in Stockholm Township, Minnesota
95 6/2/22 30,000 ducks destroyed at Duck farm Berks Pennsylvania